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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCS1
All Species:
40.61
Human Site:
S67
Identified Species:
59.56
UniProt:
Q01581
Number Species:
15
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q01581
NP_001091742.1
520
57294
S67
T
D
R
E
D
I
N
S
L
C
M
T
V
V
Q
Chimpanzee
Pan troglodytes
XP_517780
610
66491
S157
T
D
R
E
D
I
N
S
L
C
M
T
V
V
Q
Rhesus Macaque
Macaca mulatta
XP_001090857
592
65050
S139
T
D
R
E
D
I
N
S
L
C
M
T
V
V
Q
Dog
Lupus familis
XP_536483
637
69021
S184
T
D
R
E
D
I
N
S
L
C
L
T
V
V
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q8JZK9
520
57550
S67
T
D
R
E
D
I
N
S
L
C
L
T
V
V
Q
Rat
Rattus norvegicus
P17425
520
57415
S67
T
D
R
E
D
I
N
S
L
C
L
T
V
V
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506375
520
57160
S67
S
D
R
E
D
I
N
S
L
C
L
T
V
V
Q
Chicken
Gallus gallus
P23228
522
57541
S67
S
D
R
E
D
I
N
S
L
C
L
T
V
V
Q
Frog
Xenopus laevis
NP_001087380
520
57303
S67
S
D
R
E
D
I
N
S
L
C
L
T
A
V
Q
Zebra Danio
Brachydanio rerio
NP_957379
508
55918
Q63
S
L
C
L
T
V
V
Q
R
L
M
E
R
N
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524711
465
51158
D32
Q
T
E
L
E
T
F
D
G
A
S
A
G
K
Y
Honey Bee
Apis mellifera
XP_397202
453
50855
V20
V
Y
F
P
A
Q
Y
V
D
Q
T
E
L
E
Q
Nematode Worm
Caenorhab. elegans
P54871
462
51397
V28
L
Y
F
P
Q
N
F
V
D
Q
N
D
L
E
K
Sea Urchin
Strong. purpuratus
XP_801879
508
56054
S68
S
D
R
E
D
I
N
S
L
C
L
T
V
I
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P54873
461
51076
D28
Q
E
A
L
E
A
H
D
G
A
S
K
G
K
Y
Baker's Yeast
Sacchar. cerevisiae
P54839
491
54995
I58
I
K
G
I
Q
I
Y
I
P
T
Q
C
V
N
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85
87.3
78.6
N.A.
94.6
94.8
N.A.
90.1
83.9
80
77.6
N.A.
58
54.6
38.4
63.2
Protein Similarity:
100
85
87.3
80.5
N.A.
97.5
97.6
N.A.
95.3
91
88.6
87.1
N.A.
69.6
68.6
54.8
75.3
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
86.6
86.6
80
6.6
N.A.
0
6.6
0
80
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
93.3
20
N.A.
6.6
13.3
13.3
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
44
45.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
60.1
60.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
7
7
0
0
0
13
0
7
7
0
0
% A
% Cys:
0
0
7
0
0
0
0
0
0
63
0
7
0
0
0
% C
% Asp:
0
63
0
0
63
0
0
13
13
0
0
7
0
0
0
% D
% Glu:
0
7
7
63
13
0
0
0
0
0
0
13
0
13
0
% E
% Phe:
0
0
13
0
0
0
13
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
7
0
0
0
0
0
13
0
0
0
13
0
7
% G
% His:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% H
% Ile:
7
0
0
7
0
69
0
7
0
0
0
0
0
7
0
% I
% Lys:
0
7
0
0
0
0
0
0
0
0
0
7
0
13
7
% K
% Leu:
7
7
0
19
0
0
0
0
63
7
44
0
13
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
25
0
0
0
0
% M
% Asn:
0
0
0
0
0
7
63
0
0
0
7
0
0
13
0
% N
% Pro:
0
0
0
13
0
0
0
0
7
0
0
0
0
0
0
% P
% Gln:
13
0
0
0
13
7
0
7
0
13
7
0
0
0
75
% Q
% Arg:
0
0
63
0
0
0
0
0
7
0
0
0
7
0
0
% R
% Ser:
32
0
0
0
0
0
0
63
0
0
13
0
0
0
0
% S
% Thr:
38
7
0
0
7
7
0
0
0
7
7
63
0
0
0
% T
% Val:
7
0
0
0
0
7
7
13
0
0
0
0
63
57
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
13
0
0
0
0
13
0
0
0
0
0
0
0
13
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _